Pubmed.ncbi.nlm.nih.gov

FDG PET And PET/CT

FDG PET and PET/CT have been used for staging and re-staging tumour patients in numerous studies. This chapter will discuss the use and the main indications of FDG PET and PET/CT in oncology with special emphasis on lung cancer, oesophageal cancer, colorectal cancer, head and neck cancer, lymphoma and breast cancer (among other tumour entities).

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An overview of PET neuroimaging - PubMed

Posted: (52 years ago) Over the past 35 years or so, PET brain imaging has allowed powerful and unique insights into brain function under normal conditions and in disease states. Initially, as PET instrumentation continued to develop, studies were focused on brain perfusion and glucose metabolism. This permitted refinemen …

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PET-guided eBEACOPP treatment of advanced-stage …

Posted: (52 years ago) Background: The German Hodgkin Study Group's HD18 trial established the safety and efficacy of PET-guided eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses) for the treatment of advanced-stage Hodgkin lymphoma. However, because of a protocol amendment during the enrolment period (June 1, …

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Tau PET correlates with different Alzheimer's disease ...

Posted: (52 years ago) Jul 13, 2021  · PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)-related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER-2 (n = 400) and AD …

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Physical principles and technology of clinical PET imaging

Posted: (52 years ago) PET imaging technology has now improved to where a combined anatomical and functional clinical study can be completed in less than 10 minutes--although taking advantage of such high throughput potential will challenge patient management in diagnostic imaging departments. This paper reviews the physical principles underlying PET and summarises ...

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Recent developments on PET radiotracers for TSPO and …

Posted: (52 years ago) Affiliations 1 Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.; 2 Department of Neurology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China.; 3 Department of Radiopharmaceuticals Development, National …

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Combined Quantitative Assessment of Myocardial …

Posted: (52 years ago) Hybrid PET myocardial perfusion imaging (MPI) with CT allows the incorporation of coronary artery calcium (CAC) into the clinical protocol. We aimed to determine whether the combined analysis of MPI and CAC could improve the diagnostic accuracy of PET MPI in detection of obstructive coronary artery disease (CAD).

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Clinical Evaluation of PET Image Quality as a Function of ...

Posted: (52 years ago) The PET/CT scan was used as a reference and the PET/MRI acquisition time was consecutively adjusted, taking into account the decay between the scans in order to expose both systems to the same amount of the emitted signal. The acquisition times were then retrospectively reduced to assess the performance of the PET/MRI for lower count rates.

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Comparison of the protective effect of a commercially ...

Posted: (52 years ago) Objective: To evaluate effectiveness of a commercially available toxoid manufactured from western diamondback (WD) rattlesnake (Crotalus atrox) venom against envenomation of mice with WD, northern Pacific (NP) rattlesnake (Crotalus oreganus oreganus), and southern Pacific (SP) rattlesnake (Crotalus oreganus helleri) venom. Animals: 90 specific pathogen-free …

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PET: the merging of biology and imaging into molecular …

Posted: (52 years ago) PET and SPECT are molecular imaging techniques that use radiolabeled molecules to image molecular interactions of biological processes in vivo. PET imaging technologies have been developed to provide a pathway to the patient from the experimental paradigms of biological and pharmaceutical sciences i …

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PET/CT in Radiation Therapy Planning - PubMed

Posted: (52 years ago) Radiation therapy (RT) is an important component of the management of lymphoma patients. Most lymphomas are metabolically active and accumulate 18 F-fluorodeoxyglucose (FDG). Positron emission tomography with computer tomography (PET/CT) imaging using FDG is used routinely in staging and t …

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Role of PET/CT in Management of Early Lung Adenocarcinoma

Posted: (52 years ago) A retrospective analysis was conducted on the PET/CT data on ground-glass nodules (GGNs) resected from patients with stage IA lung adenocarcinoma. The efficacy of PET maximum standardized uptake value (SUV max) combined with HRCT signs in prediction of histopathologic subtype and growth pattern of lung adeno-carcinoma was evaluated. RESULTS.

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PET/CT in radiation oncology

Posted: (52 years ago) The progressive integration of positron emission tomography/computed tomography (PET/CT) imaging in radiation therapy has its rationale in the biological intertumoral and intratumoral heterogeneity of malignant lesions that require the individual adjustment of radiation dose to obtain an effective local tumor control in cancer patients.

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Forward to the Past: The Case for Quantitative PET Imaging

Posted: (52 years ago) PET is now seen as a promising tool for drug development and precision medicine-that is, a method to monitor or even predict response to therapy. Quantification is essential for precision medicine, but many studies today use simplified semiquantitative methods without properly validating them.

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Recent Developments of 18F-FET PET in Neuro-oncology

Posted: (52 years ago) Background: From the past decade to date, several studies related to O-(2- [18F]fluoroethyl)-L-tyrosine (18F-FET) positron emission tomography (PET) in brain tumours have been published in the literature. Objective: The aim of this narrative review is to summarize the recent developments and the current role of 18F-FET PET in brain tumours according to recent …

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Histologic subtype classification of non-small cell lung ...

Posted: (52 years ago) Purposes: To evaluate the capability of PET/CT images for differentiating the histologic subtypes of non-small cell lung cancer (NSCLC) and to identify the optimal model from radiomics-based machine learning/deep learning algorithms. Methods: In this study, 867 patients with adenocarcinoma (ADC) and 552 patients with squamous cell carcinoma (SCC) were …

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Clinical applications: MRI, SPECT, and PET

Posted: (52 years ago) MRI, PET, and SPECT are all used to image abnormalities in the epileptic brain. Comparison of the techniques is difficult because they measure different aspects of the epileptic process--structure, metabolism, and perfusion. SPECT is the only one that can be systematically applied during seizures, w …

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Pitfalls and Limitations of PET/CT in Brain Imaging

Posted: (52 years ago) Neurologic applications were at the forefront of PET imaging when the technique was developed in the mid-1970s. Although oncologic indications have become prominent in terms of number of studies performed worldwide, neurology remains a major field in which functional imaging provides unique information, both for clinical and research purposes.

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Roadmap toward the 10 ps time-of-flight PET challenge

Posted: (52 years ago) Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with an unprecedented sensitivity at the picomolar level, especially for cancer diagnosis and the monitoring of its response to therapy. More recently, its combination with x-ray compu …

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Fibroblast Activation Protein Inhibitor PET/CT: A ...

Posted: (52 years ago) Purpose: Fibroblast activation protein (FAP) is a cell membrane-bound serine peptidase, overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound healing/inflammatory sites. Recently, molecular PET/CT imaging with radiolabeled FAP inhibitor (FAPI) has been evaluated in different diseases. We aimed to assess its potential role based …

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68 Ga-NOTA-Evans Blue PET/CT findings in ...

Posted: (52 years ago) Background: Lymphangioleiomyomatosis (LAM) is a rare multisystem disease characterized by cystic lung disease and extrapulmonary manifestations, including lymphatic system disorder. The objective of this study was to investigate the findings of 68 Ga-NOTA-Evans Blue (NEB) PET/CT in LAM and compare it with that of 99m Tc-ASC lymphoscintigraphy.

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Cardiac PET-CT

Posted: (52 years ago) Integrated positron emission tomography computed tomography (PET/CT) scanners allow a true integration of the structure and function of the heart. Myocardial perfusion PET provides a high sensitivity (91%) and specificity (89%) for the diagnosis of obstructive coronary artery disease (CAD). But, as …

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Applications of amyloid, tau, and neuroinflammation PET ...

Posted: (52 years ago) PET is a very promising methodology for differential diagnosis and novel targets of PET imaging might also serve as biomarkers for disease-modifying therapeutic interventions. This review provides an overview of the current status and applications of in vivo molecular imaging of AD pathology, specifically amyloid, tau, and microglial activation.

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PET-guided omission of radiotherapy in early-stage ...

Posted: (52 years ago) PET-guided omission of radiotherapy in early-stage unfavourable Hodgkin lymphoma (GHSG HD17): a multicentre, open-label, randomised, phase 3 trial Lancet Oncol. 2021 Feb;22(2):223-234. doi: 10.1016/S1470-2045(20)30601-X. Authors Peter Borchmann ...

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The value of ¹⁸F-FDG PET/CT in the management of malignant ...

Posted: (52 years ago) PET/CT is valuable in MPNST management because of its high accuracy in staging and high sensitivity and accuracy in restaging as well as improvements in treatment planning. MTV from baseline staging studies is predictive of survival. Additionally, change in SUVmax, TLG, and MTV accurately predicted …

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Assessment of Myocarditis: Cardiac MR, PET/CT, or PET/MR?

Posted: (52 years ago) The Lake Louis Criteria (CLL) of cardiac MR is widely used for the diagnosis of myocarditis. It has an overall acceptable sensitivity of 67% and specificity of 91% for acute myocarditis but does not have the same accuracy for chronic myocarditis. FDG PET/CT is capable of assessing myocarditis by pro …

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Expression and Purification of Recombinant Proteins Using ...

Posted: (52 years ago) The pET System is the most powerful system yet developed for the cloning and expression of recombinant proteins in Escherichia coli Target genes are cloned in pET plasmids under control of strong bacteriophage T7 transcription and (optionally) translation signals, expression is induced by providing a source of T7 RNA polymerase in the host cell (1-2).

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PET Imaging of Tumor PD-L1 Expression with a Highly ...

Posted: (52 years ago) All biodistribution, PET imaging, autoradiography, and immunohistochemical staining studies revealed that 68 Ga-NOTA-Nb109 specifically accumulated in A375-hPD-L1 tumor, with a maximum uptake of 5.0% ± 0.35% injected dose/g at 1 h. Conclusion: 68 Ga-NOTA-Nb109 holds great potential for noninvasive PET imaging of the PD-L1 status in tumors and ...

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PET imaging of neural activity, β-amyloid, and tau in ...

Posted: (52 years ago) Positron emission tomography (PET) with radiotracers targeting these age-related changes has been increasingly employed to clarify the sequence of their occurrence and the evolution of clinically cognitive deficits. Herein, we reviewed recent literature on PET-based imaging of normal human brain aging in terms of neural activity, Aβ, and tau.

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Did the COVID-19 Pandemic Spark a Public Interest in Pet ...

Posted: (52 years ago) In conclusion, the global interest in pet adoptions surged in the early phase of the pandemic but not sustainable. With the launch of COVID-19 vaccines, there is a concern for separation anxiety and possible abandonment of these newly adopted pets when the owners would leave their homes for work in the future.

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Salvage therapy for prostate cancer after radical ...

Posted: (52 years ago) The optimal pre-salvage therapy investigational workup for patients who experience biochemical recurrence should, therefore, include novel techniques such as PET imaging and genomic analysis of radical prostatectomy specimen tissue, as well as consideration of more traditional clinical variables such as PSA value, PSA kinetics, Gleason score ...

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NEMA NU2-2012 performance measurements of the United ...

Posted: (52 years ago) The PET performance of the newly introduced integrated PET/MR system is not significantly affected by the simultaneous operation of an MR sequence (2-point DIXON sequence). Measurement results demonstrate comparable performance with other state-of-the-art PET/MR systems. The clinical benefits of hig …

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Fluorine-18 labelled building blocks for PET tracer ...

Posted: (52 years ago) Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers.

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The use of PET/CT in prostate cancer - PubMed

Posted: (52 years ago) Background: Positron emission tomography/computed tomography (PET/CT) has recently emerged as a promising diagnostic imaging platform for prostate cancer. Several radiolabelled tracers have demonstrated efficacy for cancer detection in various clinical settings. In this review, we aim to illustrate the diverse use of PET/CT with different tracers for the detection of …

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18F-FDG PET/CT in gastric MALT lymphoma: a bicentric ...

Posted: (52 years ago) The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value (SUVmax), lesion-to-liver SUVmax ratio, and lesion-to-blood pool SUVmax ratio and compared with Ann Arbor stage, epidemiological (age, sex), histological (presence of gastritis, ulcer, H. pylori infection, plasmacytic differentiation ...

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Ultrasensitive detection of malignant melanoma using PET ...

Posted: (52 years ago) Ultrasensitive detection of malignant melanoma using PET molecular imaging probes. Proc Natl Acad Sci U S A. 2020 Jun 9;117 (23):12991-12999. …

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Amyloid-β PET and CSF in an autopsy-confirmed cohort

Posted: (52 years ago) Objective: Accumulation of amyloid-β is among the earliest changes in Alzheimer's disease (AD). Amyloid-β positron emission tomography (PET) and Aβ 42 in cerebrospinal fluid (CSF) both assess amyloid-β pathology in-vivo, but 10-20% of cases show discordant (CSF+/PET- or CSF-/PET+) results. The neuropathological correspondence with amyloid-β CSF/PET discordance …

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18 F-FDG brain PET hypometabolism in patients with long ...

Posted: (52 years ago) Conclusion: This study demonstrates a profile of brain PET hypometabolism in long COVID patients with biologically confirmed SARS-CoV-2 and persistent functional complaints more than 3 weeks after the initial infection symptoms, involving the olfactory gyrus and connected limbic/paralimbic regions, extended to the brainstem and the cerebellum.

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FDG-PET/CT findings in systemic mastocytosis: a French ...

Posted: (52 years ago) Introduction: Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. Methods: We retrospectively identified patients with an established diagnosis of systemic mastocytosis (SM), according to the WHO criteria, who …

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Diagnostic Accuracy of MRI and Additional [18F]FDG-PET for ...

Posted: (52 years ago) A good diagnostic accuracy was found for MRI and additional [18F]FDG-PET for bvFTD in patients with late onset behavioral changes. Caution with the interpretation of neuroimaging results should especially be taken in cases with a genetic background and in cases with a primary psychiatric differentia …

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The Place of FDG PET/CT in Renal Cell Carcinoma: Value and ...

Posted: (52 years ago) Unlike for most other malignancies, application of FDG PET/CT is limited for renal cell carcinoma (RCC), mainly due to physiological excretion of 18F-fluoro-2-deoxy-2-d-glucose (FDG) from the kidneys, which decreases contrast between renal lesions and normal tissue, and may obscure or mask the lesio …

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In vivo imaging of mitochondrial membrane potential in non ...

Posted: (52 years ago) By using PET imaging of 18 F-BnTP, we profile mitochondrial membrane potential in autochthonous mouse models of lung cancer, and find distinct functional mitochondrial heterogeneity within subtypes of lung tumours. The use of 18 F-BnTP PET imaging enabled us to functionally profile mitochondrial membrane potential in live tumours.

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68Ga-PSMA-11 PET/CT derived quantitative volumetric tumor ...

Posted: (52 years ago) Our results suggest that 68 Ga-PSMA-11 PET/CT might be a valuable tool for the detection and follow-up of bone metastases in patients with metastasized prostate cancer. 68 Ga-PSMA-11 PET-derived quantitative volumetric parameters demonstrated a highly significant correlation with …

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The lungs were on fire: a pilot study of 18 F-FDG PET/CT ...

Posted: (52 years ago) PET/CT scans and other characteristics of patients who met the inclusion and exclusion criteria were collected and analysed. Results: A total of 61 IIM-ILD patients were enrolled in this study. Twenty-one patients (34.4%) developed RP-ILD, and 24 patients (39.3%) died during follow-up.

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Brown Adipose Tissue: Multimodality Evaluation by PET, MRI ...

Posted: (52 years ago) Objective: This study aimed to compare the associations of positron emission tomography (PET), magnetic resonance (MR), and infrared thermography (IRT) imaging modalities with energy expenditure (EE) after brown adipose tissue (BAT) activation using capsinoid ingestion and cold exposure. Methods: Twenty participants underwent PET-MR, IRT imaging, and whole …

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Performance of 18F-fluoro-ethyl-tyrosine (18F-FET) PET for ...

Posted: (52 years ago) (18)F-FET PET demonstrated excellent performance for diagnosing PBTs. Strict standardization of PET acquisition protocols and prospective, multicenter studies investigating the added value over current MRI are now needed to establish (18)F …

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