Pubmed.ncbi.nlm.nih.gov

The Evaluation Of Hypermetabolic Mediastinal-hilar Lymph Nodes - PubMed

Background/aim: We aimed to define the optimal SUV(max) cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA). Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a …

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NIA-AA Research Framework: Toward a biological definition of …

Posted: (53 years ago) In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease. Scientific progress in the interim led to an initiative by the National Institute on Aging and …

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FDG PET/CT in the liver: lesions mimicking malignancies

Posted: (53 years ago) Purpose: 18F-fluorodeoxyglucose (FDG) PET/CT is invaluable in managing liver lesions, in particular in the evaluation of suspected liver metastases. It is both sensitive and specific in detecting liver metastases from a wide range of primary cancers, and may change clinical management, most commonly by detecting additional lesions and decreasing the number of …

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COVID-19 mRNA Vaccination-Induced Lymphadenopathy Mimics ... - PubMed

Posted: (53 years ago) Apr 01, 2021  · We present here a 72-year-old man with mantle cell lymphoma who has completed chemotherapy and achieved complete metabolic response to the therapy 10 months ago. Series follow-up FDG PET/CT scans have been negative for lymphoma. Current FDG PET/CT scan showed a new cluster of subcentimeter left axillary lymphadenopathy with avid FDG uptake.

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68 Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer

Posted: (53 years ago) The recent development of quinoline-based PET tracers that act as fibroblast-activation-protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is overexpressed by cancer-associated fibroblasts of several tumor entities. Here, we quantify the tumor uptake on 68 …

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Psilocybin-assisted treatment for alcohol dependence: a proof-of ...

Posted: (53 years ago) Several lines of evidence suggest that classic (5HT2A agonist) hallucinogens have clinically relevant effects in alcohol and drug addiction. Although recent studies have investigated the effects of psilocybin in various populations, there have been no studies on the efficacy of psilocybin for alcohol dependence.

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A bacterium that degrades and assimilates poly(ethylene ... - PubMed

Posted: (53 years ago) Mar 11, 2016  · By screening natural microbial communities exposed to PET in the environment, we isolated a novel bacterium, Ideonella sakaiensis 201-F6, that is able to use PET as its major energy and carbon source. When grown on PET, this strain produces two enzymes capable of hydrolyzing PET and the reaction intermediate, mono(2-hydroxyethyl) terephthalic acid.

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Machine learning-aided engineering of hydrolases for PET ...

Posted: (53 years ago) Plastic waste poses an ecological challenge 1-3 and enzymatic degradation offers one, potentially green and scalable, route for polyesters waste recycling 4.Poly(ethylene terephthalate) (PET) accounts for 12% of global solid waste 5, and a circular carbon economy for PET is theoretically attainable through rapid enzymatic depolymerization followed by repolymerization or …

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State-of-the-art of FAPI-PET imaging: a systematic review and …

Posted: (53 years ago) Introduction: Fibroblast activation protein-α (FAPα) is overexpressed on cancer-associated fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target for therapeutic and molecular imaging applications. [68 Ga]Ga-labelled radiopharmaceuticals-FAP-inhibitors (FAPI)-have been developed for PET.We systematically reviewed and meta …

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Reversal of synapse loss in Alzheimer mouse models by ... - PubMed

Posted: (53 years ago) Jun 02, 2022  · In aged mouse models of AD (APPswe/PS1ΔE9 overexpressing transgenic and App NL-G-F /hMapt double knock-in), SAM treatment fully restored synaptic density as measured by [18 F]SynVesT-1 PET for SV2A and by histology, and the therapeutic benefit persisted after drug washout. Phospho-TAU accumulation in double knock-in mice was also reduced by ...

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Staphylococcus lugdunensis: Review of Epidemiology, Complications…

Posted: (53 years ago) Jun 24, 2020  · Staphylococcus lugdunensis is a species of coagulase-negative staphylococci (CNS) that induces a variety of infectious diseases, including skin and soft tissue infection (SSTI), infective endocarditis (IE), and bone and PJI. This review article underscores the important points in the literature about S. lugdunensis infections, including its epidemiology, diagnosis, and …

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Alzheimer's disease - PubMed

Posted: (53 years ago) Jul 30, 2016  · Tau PET might offer new insights and be of great help in differential diagnosis and selection of patients for trials. In the search for understanding the disease mechanism and keys to treatment, research is moving increasingly into the earliest phase of disease. Preclinical Alzheimer's disease is defined as biomarker evidence of Alzheimer's ...

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Blood-based biomarkers for Alzheimer's disease: towards

Posted: (53 years ago) Concentrations in blood of amyloid and phosphorylated tau proteins associate with the corresponding concentrations in CSF and with amyloid-PET or tau-PET scans. Moreover, other blood-based biomarkers of neurodegeneration, such as neurofilament light chain and glial fibrillary acidic protein, appear to provide information on disease progression ...

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Feline Asthma: Diagnostic and Treatment Update - PubMed

Posted: (53 years ago) Asthma is an important allergic lower-airway disease in cats affecting approximately 1% to 5% of the pet cat population. New diagnostics are being developed to help better differentiate asthma from other lower-airway diseases and improve monitoring. In addition, new treatments are being developed to help in refractory cases or in those cases in ...

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The glymphatic pathway in neurological disorders - PubMed

Posted: (53 years ago) Other PET studies have shown that CSF clearance of Aβ and tau tracers is reduced in patients with Alzheimer's disease compared with healthy controls. The observed reduction in CSF clearance was associated with increasing grey-matter concentrations of Aβ in the human brain, consistent with findings in mice showing that decreased glymphatic ...

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New response evaluation criteria in solid tumours: revised RECIST ...

Posted: (53 years ago) A key question considered by the RECIST Working Group in developing RECIST 1.1 was whether it was appropriate to move from anatomic unidimensional assessment of tumour burden to either volumetric anatomical assessment or to functional assessment with PET or MRI. It was concluded that, at present, th …

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Cancer of the gastroesophageal junction: a diagnosis ... - PubMed

Posted: (53 years ago) Staging work-up with endoscopy, endosonography, and PET is essential to inform the choice of neoadjuvant treatment and surgical approach to GEJ adenocarcinoma. Surgery remains the only curative treatment and should be undertaken in specialized centers.

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Recommendations for initial evaluation, staging, and response ...

Posted: (53 years ago) Sep 20, 2014  · PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale. The product of the perpendicular diameters of a single node can be used to identify progressive disease. Routine surveillance scans are discouraged. These recommendations should improve evaluation of patients with lymphoma and enhance the ability to compare ...

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Non-small-cell lung cancer - PubMed

Posted: (53 years ago) May 21, 2015  · Lung cancer is one of the most frequently diagnosed cancers and is the leading cause of cancer-related death worldwide. Non-small-cell lung cancer (NSCLC), a heterogeneous class of tumours, represents approximately 85% of all new lung cancer diagnoses. Tobacco smoking remains the main risk factor fo …

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Tapering of SSRI treatment to mitigate withdrawal symptoms

Posted: (53 years ago) We examined the PET imaging data of serotonin transporter occupancy by SSRIs and found that hyperbolically reducing doses of SSRIs reduces their effect on serotonin transporter inhibition in a linear manner. We therefore suggest that SSRIs should be tapered hyperbolically and slowly to doses much lower than those of therapeutic minimums, in ...

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Breast cancer diagnosis: Imaging techniques and biochemical …

Posted: (53 years ago) Breast cancer is a complex disease which is found as the second cause of cancer-associated death among women. Accumulating of evidence indicated that various factors (i.e., gentical and envirmental factors) could be associated with initiation and progression of breast cancer. Diagnosis of breast can …

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Gastric cancer - PubMed

Posted: (53 years ago) Aug 29, 2020  · Gastric cancer is diagnosed histologically after endoscopic biopsy and staged using CT, endoscopic ultrasound, PET, and laparoscopy. It is a molecularly and phenotypically highly heterogeneous disease. The main treatment for early gastric cancer is endoscopic resection. Non-early operable gastric cancer is treated with surgery, which should ...

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The detection of monkeypox in humans in the Western Hemisphere

Posted: (53 years ago) Jan 22, 2004  · Background: During May and June 2003, an outbreak of febrile illness with vesiculopustular eruptions occurred among persons in the midwestern United States who had had contact with ill pet prairie dogs obtained through a common distributor. Zoonotic transmission of a bacterial or viral pathogen was suspected. Methods: We reviewed medical records, conducted …

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Cell-programmed nutrient partitioning in the tumour

Posted: (53 years ago) Cancer cells characteristically consume glucose through Warburg metabolism 1, a process that forms the basis of tumour imaging by positron emission tomography (PET).Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metabolism in the tumour microenvironment (TME) contributes to immune evasion by tumour cells 2-4.However, …

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Effects of a single preappointment dose of gabapentin on signs of ...

Posted: (53 years ago) Nov 15, 2017  · ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly assigned to receive a capsule containing 100 mg of gabapentin (13.0 to 29.4 mg/kg [5.9 to 13.4 mg/lb]) or placebo (lactose powder) prior to the first ...

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Monkeypox - PubMed

Posted: (53 years ago) Jul 16, 2022  · Monkeypox virus was first isolated and identified in 1958 when monkeys shipped from Singapore to a Denmark research facility fell ill. However, the first confirmed human case was in 1970 when the virus was isolated from a child in the Democratic Republic of Congo suspected to have smallpox. Coincid …

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Parkinson disease - PubMed

Posted: (53 years ago) Mar 23, 2017  · Parkinson disease is the second-most common neurodegenerative disorder that affects 2-3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological h …

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Alzheimer's disease - PubMed

Posted: (53 years ago) Apr 24, 2021  · Novel biomarkers include PET scans and plasma assays for amyloid β and phosphorylated tau, which show great promise for clinical and research use. Multidomain lifestyle-based prevention trials suggest cognitive benefits in participants with increased risk of dementia. Lifestyle factors do not directly affect Alzheimer's disease pathology, but ...

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Lisocabtagene maraleucel for patients with relapsed or ... - PubMed

Posted: (53 years ago) Sep 19, 2020  · Background: Lisocabtagene maraleucel (liso-cel) is an autologous, CD19-directed, chimeric antigen receptor (CAR) T-cell product. We aimed to assess the activity and safety of liso-cel in patients with relapsed or refractory large B-cell lymphomas. Methods: We did a seamless design study at 14 cancer centres in the USA. We enrolled adult patients (aged ≥18 years) …

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The amyloid hypothesis of Alzheimer's disease at 25 years

Posted: (53 years ago) Jun 01, 2016  · In humans, new studies show that low cerebrospinal fluid (CSF) Aβ42 and amyloid-PET positivity precede other AD manifestations by many years. Most importantly, recent trials of three different Aβ antibodies (solanezumab, crenezumab, and aducanumab) have suggested a slowing of cognitive decline in post hoc analyses of mild AD subjects.

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CTCF-Mediated Human 3D Genome Architecture Reveals …

Posted: (53 years ago) Dec 17, 2015  · Spatial genome organization and its effect on transcription remains a fundamental question. We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) strategy to comprehensively map higher-order chromosome folding and specific chromatin interactions mediated by CCCTC-binding factor (CTCF) and RNA polymerase II …

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Blood phosphorylated tau 181 as a biomarker for Alzheimer's ... - PubMed

Posted: (53 years ago) Background: CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer's disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use as clinical diagnostic tools. CSF tau phosphorylated at threonine 181 (p-tau181) is a highly specific biomarker for Alzheimer's disease pathology.

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[ 177 Lu]Lu-PSMA-617 versus cabazitaxel in patients with ... - PubMed

Posted: (53 years ago) Feb 27, 2021  · PET eligibility criteria for the trial were PSMA-positive disease, and no sites of metastatic disease with discordant FDG-positive and PSMA-negative findings. Men were randomly assigned (1:1) to [ 177 Lu]Lu-PSMA-617 (6·0-8·5 GBq intravenously every 6 weeks for up to six cycles) or cabazitaxel (20 mg/m 2 intravenously every 3 weeks for up to ...

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Risk factors and disease profile of post-vaccination SARS-CoV-2 ...

Posted: (53 years ago) Background: COVID-19 vaccines show excellent efficacy in clinical trials and effectiveness in real-world data, but some people still become infected with SARS-CoV-2 after vaccination. This study aimed to identify risk factors for post-vaccination SARS-CoV-2 infection and describe the characteristics of post-vaccination illness.

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Invasive Pulmonary Aspergillosis - PubMed

Posted: (53 years ago) Invasive pulmonary aspergillosis (IPA) remains difficult to diagnose and to treat. Most common risk factors are prolonged neutropenia, hematopoietic stem cell or solid organ transplantation, inherited or acquired immunodeficiency, administration of steroids or other immunosuppressive agents including monoclonal antibodies and new small molecules used for cancer therapy.

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Anxiety and depression symptoms after COVID-19 infection ... - PubMed

Posted: (53 years ago) 8 PET Centre, Division of Imaging Sciences and Biomedical Engineering, King's College London, London, UK. 9 Department of Twin Research and Genetic Epidemiology, King's College London, London, UK [email protected]

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