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Antibodies And Antimatter: The Resurgence Of Immuno-PET

Convergence of knowledge regarding key biomarkers that define normal biologic processes and disease with protein and imaging technology makes this an opportune time to revisit the combination of antibodies and PET, or immuno-PET.

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CD8-targeted PET Imaging of Tumor Infiltrating T cells in ...

Posted: (52 years ago) Jan 01, 2022  · Methods: We conducted a phase 1 first-in-human PET imaging study using an anti-CD8 radiolabeled minibody, 89Zr-Df-IAB22M2C, to detect whole body and tumor CD8+ leukocyte distribution in patients with metastatic solid tumors. Patients received 111 MBq of 89Zr-Df-IAB22M2C followed by serial PET scans over a 5-7-day period.

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PET/CT for Therapy Response Assessment in Lymphoma ...

Posted: (52 years ago) May 01, 2009  · PET with 18F-FDG is a standard staging procedure for most lymphoma subtypes. Performed during and after therapy for Hodgkin lymphoma (HL) and aggressive non-Hodgkin lymphoma (NHL), 18F-FDG PET results have a high prognostic value and correlate with survival. 18F-FDG PET has been incorporated into revised response criteria for aggressive …

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Comparison of Static and Dynamic 18F-FDG PET/CT for ...

Posted: (52 years ago) Nov 01, 2019  · PET imaging with 18F-FDG followed by mathematic modeling of the pulmonary uptake rate (Ki) is the gold standard for assessment of pulmonary inflammation in experimental studies of acute respiratory distress syndrome (ARDS). However, dynamic PET requires long imaging and allows the assessment of only 1 cranio-caudal field of view (∼15 cm). We …

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68Ga-PSMA-11 NDA Approval: A Novel and Successful …

Posted: (52 years ago) Feb 01, 2021  · PET imaging with 68 Ga-PSMA-11 has been adopted in many countries for initial staging and restaging and for localizing biochemical recurrence of prostate cancers. In the United States, it was under investigational use until December 1, 2020, when University of California San Francisco (UCSF, New Drug Application [NDA] 212643) and University of California Los …

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Deep-Inspiration Breath-Hold PET/CT of the Thorax ...

Posted: (52 years ago) Jan 01, 2007  · The goal of this study was to describe our initial experience with the deep-inspiration breath-hold (DIBH) technique in combined PET/CT of the thorax. This article presents particular emphasis on the technical aspects required for clinical implementation. Methods: In the DIBH technique, the patient is verbally coached and brought to a reproducible deep inspiration …

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Dynamic whole-body PET imaging: principles, potentials …

Posted: (52 years ago) May 01, 2018  · 1158 Objectives: To demonstrate that dynamic whole-body (DWB) PET is a clinical imaging tool with significant potential. DWB PET can be performed within reasonable clinical imaging times and enables generation of multiple types of PET images with complementary information in a single imaging session (

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PET/CT Today and Tomorrow | Journal of Nuclear Medicine

Posted: (52 years ago) Jan 01, 2004  · Accurate anatomic localization of functional abnormalities seen with PET is known to be problematic. Even though nonspecific tracers such as 18F-FDG visualize certain normal anatomic structures, the spatial resolution is generally inadequate for localization of pathology. Combining PET with a high-resolution anatomic imaging modality such as CT can resolve the …

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Limitations of CT During PET/CT | Journal of Nuclear …

Posted: (52 years ago) Oct 01, 2007  · PET/CT; diagnostic CT; limitations of CT; Diagnostic CT scanning has been the mainstay of oncologic imaging over the past 25 y. By the end of the 1990s, 18 F-FDG PET/CT was developed, offering the first opportunity to combine metabolic and anatomic information leading to a powerful new combined-modality imaging examination. Methodologic and …

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Fibroblast Activation Protein–Specific PET/CT Imaging in ...

Posted: (52 years ago) Jan 01, 2022  · PET imaging was correlated with CT-based fibrosis scores. Time–activity curves derived from dynamic imaging were analyzed. FAP immunohistochemistry of 4 human fILD biopsy samples and of fibrotic lungs of Nedd4-2−/− mice was performed. Results: fILD lesions as well as LC showed markedly elevated 68Ga-FAPI uptake (density-corrected SUVmax ...

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PET/CT in Clinical Practice | Journal of Nuclear Medicine

Posted: (52 years ago) Apr 01, 2008  · PET/CT has an ability that has revolutionized the detection and staging of various tumors: the ability to accurately identify the anatomic location of abnormal metabolic activity. This new technology has also had a significant impact on cardiology and neurology. This small handbook of 10 chapters

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Variations in Clinical PET/CT Operations: Results of an ...

Posted: (52 years ago) Feb 01, 2011  · PET/CT was most frequently used for applications in torso or whole-body oncology (87%), radiation therapy planning (4%), cardiology (4%), and neurology (5%). The average interval of fasting before an 18 F-FDG PET/CT examination was 7 ± 3 h (range, 4–12 h). Blood glucose levels were measured at 99% of sites, but acceptable maximal glucose ...

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Appropriate Use Criteria for Prostate-Specific Membrane ...

Posted: (52 years ago) Jan 01, 2022  · PSMA PET Imaging Protocols and Reporting. The recommended imaging protocols for 68 Ga-PSMA-11 and 18 F-DCFPyL are similar. In short, the administered activity, based on the prescribing information, is 111–259 MBq (3–7 mCi) for 68 Ga-PSMA-11 and 296–370 MBq (8–10 mCi) for 18 F-DCFPyL. The uptake time for 68 Ga-PSMA-11 is 50–100 …

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Update on Time-of-Flight PET Imaging | Journal of Nuclear ...

Posted: (52 years ago) Jan 01, 2015  · Time-of-flight (TOF) PET was initially introduced in the early days of PET. The TOF PET scanners developed in the 1980s had limited sensitivity and spatial resolution, were operated in 2-dimensional mode with septa, and used analytic image reconstruction methods. The current generation of TOF PET scanners has the highest sensitivity and spatial resolution ever …

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18F-DOPA PET and PET/CT | Journal of Nuclear Medicine

Posted: (52 years ago) Oct 01, 2007  · F-DOPA PET and PET/CT. In the study of Timmers et al. ( 1) published in this issue of The Journal of Nuclear Medicine, 11 patients with pheochromocytoma and extraadrenal abdominal paraganglioma were evaluated with 18 F-dihydroxyphenylalanine (DOPA) PET at baseline and after carbidopa administration. This inhibitor of peripheral aromatic amino ...

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The change in management by 18F-DCFPyL PSMA PET scanning ...

Posted: (52 years ago) Jan 20, 2022  · Rationale: Prostate specific membrane antigen (PSMA) tracers have increased sensitivity in detection of prostate cancer compared to conventional imaging. We assessed the management impact of 18F-DCFPyL PET/CT in patients with PSA recurrence post radical prostatectomy (RP) and report early biochemical response in patients who underwent radiation …

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Principles of PET/MR Imaging | Journal of Nuclear Medicine

Posted: (52 years ago) Jun 01, 2014  · Hybrid PET/MR systems have rapidly progressed from the prototype stage to systems that are increasingly being used in the clinics. This review provides an overview of developments in hybrid PET/MR systems and summarizes the current state of the art in PET/MR instrumentation, correction techniques, and data analysis. The strong magnetic field requires …

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Why Nearly All PET of Abdominal and Pelvic Cancers Will Be ...

Posted: (52 years ago) Jan 01, 2004  · Clinical experience at Johns Hopkins and published literature regarding PET/CT applications in the abdomen and pelvis are reviewed, and the strengths and limitations of this evolving technology are summarized. More than 2,700 whole-body PET/CT scans including the abdomen and pelvis were performed for clinical indications by our nuclear medicine service …

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18F-FDG Positron Emission Tomography in Myocardial ...

Posted: (52 years ago) Sep 01, 2021  · We assessed image quality using a practical and time-efficient protocol for intravenous glucose loading and insulin injection prior to administration of 18F-fluorodeoxyglucose (18F-FDG) for PET myocardial viability evaluation in patients with ischemic cardiomyopathy, with and without type 2 diabetes mellitus. Methods: Metabolic preparation period (MPP) or optimal …

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Practical Guide for Interpreting and Reporting Cardiac PET ...

Posted: (52 years ago) Nov 01, 2021  · One of the most exciting and useful advances in nuclear cardiology is the opportunity to measure myocardial blood flow (MBF) routinely as part of myocardial perfusion imaging (MPI) with positron emission tomography (PET). Incorporating MBF into the MPI evaluation improves diagnosis and assessment of

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Efficient delay correction for total-body PET kinetic ...

Posted: (52 years ago) Dec 20, 2021  · Quantitative kinetic modeling requires an input function (IF). A non-invasive image-derived IF (IDIF) can be obtained from dynamic PET images. However, a robust IDIF location, (e.g. aorta), may be far away from a tissue of interest, particularly in total-body PET, introducing a time delay between the IDIF and the tissue. The standard practice of joint …

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PET/CT in Colorectal Cancer | Journal of Nuclear Medicine

Posted: (52 years ago) Nov 01, 2003  · PET/CT in Colorectal Cancer. After the prototype PET/CT scanner was introduced by David Townsend and his team, dual-modality imaging has remained in the spotlight. Their device combined a PET scanner and a CT scanner, permitting subsequent mechanical fusion of the images separately acquired by each modality. They produced a fused head-and-neck ...

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18F-FET PET Compared with 18F-FDG PET and CT in Patients ...

Posted: (52 years ago) Feb 01, 2006  · Recent studies suggest a somewhat selective uptake of O- (2-[18F]fluoroethyl)-l-tyrosine (FET) in cerebral gliomas and in squamous cell carcinoma (SCC) and a good distinction between tumor and inflammation. The aim of this study was to investigate the diagnostic potential of 18F-FET PET in patients with SCC of the head and neck region by comparing that tracer …

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18F-fluorocholine PET/CT is more sensitive than 11C ...

Posted: (52 years ago) Aug 01, 2021  · The PET/CT results were classified into 3 categories (positive, inconclusive or negative) based on the nodular aspect of tracer uptake and the visualisation of corresponding nodules on CT. The PET/CT results were correlated with the surgical and histopathological findings used as gold standard.

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Comparison of 11C-Pittsburgh compound-B and 18F ...

Posted: (52 years ago) Dec 16, 2021  · PET imaging with β-amyloid ligands is emerging as a molecular imaging technique targeting white matter integrity and demyelination. β-amyloid PET ligands such as “11C-Pittsburgh compound-B” (11C-PiB) have been considered for quantitative measurement of myelin content changes in multiple sclerosis (MS), but 11C-PiB is not commercially available given its short …

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Dynamic Amyloid PET: Relationships to Flortaucipir Tau PET ...

Posted: (52 years ago) May 01, 2021  · Rationale: Measuring amyloid and predicting tau status using a single amyloid positron emission tomography (PET) study would be valuable for assessing brain AD pathophysiology. We hypothesized that early-frame amyloid PET (efAP) correlates with the presence of tau pathology because the initial regional brain concentrations of radioactivity are …

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18F-FDG PET for Detecting Myocardial Viability: Validation ...

Posted: (52 years ago) Jan 01, 2005  · 18F-FDG PET is an important diagnostic tool for detecting myocardial viability in patients with coronary artery disease. In combination with perfusion scanning, 18F-FDG PET allows differentiation between reversibly and irreversibly damaged myocardium and selection of patients likely to benefit from revascularization. Viability PET is usually performed in two …

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18F-Fluorocholine: A New Oncologic PET Tracer | Journal of ...

Posted: (52 years ago) Dec 01, 2001  · HEAD AND NECK CANCER. 11 C-Choline PET and FDG PET showed positive tumor uptake. Healthy organs of positive uptake (e.g., salivary glands in 11 C-choline PET) provided good landmarks for the localization of tumors. When the head and neck cancer was treated by radiotherapy, the therapeutic response measured by 11 C-choline PET was rapid, …

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The impact of semi-automatic segmentation methods on ...

Posted: (52 years ago) Jan 01, 2022  · Introduction: Consensus about a standard segmentation method to derive metabolic tumor volume (MTV) in classical Hodgkin lymphoma (cHL) is lacking, and it is unknown how different segmentation methods influence quantitative PET features. Therefore, we aimed to evaluate the delineation and completeness of lesion selection and the need for manual …

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Clinical Performance of PET/CT in Evaluation of Cancer ...

Posted: (52 years ago) Aug 01, 2003  · This study assessed the clinical performance of a combined PET/CT system using 18F-FDG in oncologic patients. Methods: 18F-FDG PET/CT was used to evaluate 204 patients with 586 suspicious lesions. All patients had available follow-up data, enabling assessment of the clinical significance of hybrid PET/CT findings. Differences in interpretation between PET, CT, …

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Brain 18F-FDG PET in the Diagnosis of Neurodegenerative ...

Posted: (52 years ago) Apr 01, 2004  · The clinical identification and differential diagnosis of dementias is especially challenging in the early stages, but the need for early, accurate diagnosis has become more important, now that several medications for the treatment of mild to moderate Alzheimer’s disease (AD) are available. Many neurodegenerative diseases produce significant brain-function …

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First Tau PET Tracer Approved: Toward Accurate In Vivo ...

Posted: (52 years ago) Oct 01, 2020  · As such, 18 F-flortaucipir is the first approved tau PET tracer. This is a great achievement and a major step forward in our mission to improve AD diagnosis. AD is histopathologically characterized by the presence of β-amyloid plaques and neurofibrillary tangles in the brain. To detect amyloid pathology in vivo, several PET tracers are approved.

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Appropriate Use Criteria for PET Myocardial Perfusion ...

Posted: (52 years ago) PET MPI < 90 d after abnormal results of a prior exercise ECG test without intervening revascularization is considered rarely appropriate (score 1). A goal-directed lifestyle and medical therapeutic intervention with or without revascularization appears to be appropriate without additional perfusion imaging ( 163 ).

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The Advantages of Nanoparticles for PET | Journal of ...

Posted: (52 years ago) Nov 01, 2009  · Nanoparticles have an advantage for molecular imaging in that many functionalities can be added to the surface and interior of the particle. This brief review focuses on the design of nanomaterials that take advantage of PET. An evolutionary approach is presented, leading to the optimization of the nanoparticle composition and structure to achieve controlled …

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PET/MRI Versus PET/CT for Whole-Body Staging: Results from ...

Posted: (52 years ago) Aug 01, 2020  · PET/MRI. In whole-body imaging, only contrast-enhanced T1-weighted sequences were obtained. Depending on the clinical indication, additional high-resolution MRI sequences were acquired for evaluation of local tumor extent (e.g., in prostate or breast cancer) or for metastasis detection (e.g., for the liver in gastrointestinal tumors), when needed.

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Weight-Based, Low-Dose Pediatric Whole-Body PET/CT ...

Posted: (52 years ago) PET/CT Protocol Design. We developed weight-based, whole-body 18 F-FDG PET/CT protocols and estimated the radiation exposure and cancer risk of these examinations. All patients underwent identical preparation (6-h nothing by mouth except water, warm and quiescent uptake environment), were scanned 1 h after injection of 18 F-FDG, and were imaged during quiet …

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